Find Proteins of Unknown Structure - Fast & Easy

  • Thread starter karthik3k
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In summary, to find a list of proteins with unknown structure, you can check the ExPASy Molecular Biology Server for protein sequences and then cross-reference with the Protein Data Bank for available 3-D structures. Alternatively, you can also visit the Scripps website for information on metalloproteins.
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karthik3k
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I want a list of Proteins of Unknown structure...
Where shall i find it ?
 
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Don't most proteins have an unknown 3D (tertiary or quarternairy) structure? Or are you talking about the aminoacid (primary) structure?
 
  • #3
The online repository for protein sequences is the ExPASy Molecular Biology Server. The online repository for 3-D protein structures (determined by x-ray crystallography, NMR, etc.) is the Protein Data Bank .

Insofar as I know, there is no convenient listing of proteins without an experimentally determined 3-D structure. Your best bet is to find a protein in the ExPASy files and then check the PDB to see if there is a structure available. Trust me, a little bit of hard work never killed anyone. :)

You may also want to take a look at the http://metallo.scripps.edu/ at Scripps if you're interested in that sort of thing.
 
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1. What is the purpose of finding proteins of unknown structure?

The purpose of finding proteins of unknown structure is to gain a better understanding of their functions and potential uses in various biological processes. This information can also aid in the development of new drugs and treatments for diseases.

2. How do scientists find proteins of unknown structure?

Scientists use various techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy to determine the structure of proteins. These methods involve analyzing the physical and chemical properties of the protein to create a 3D model.

3. What are the benefits of finding proteins of unknown structure?

There are several benefits to finding proteins of unknown structure, including understanding their role in biological processes, identifying potential drug targets, and developing new treatments for diseases. It can also lead to the discovery of new enzymes and proteins with unique functions.

4. How long does it take to find proteins of unknown structure?

The time it takes to find proteins of unknown structure varies depending on the complexity of the protein and the methods used. It can take anywhere from a few months to several years to determine the structure of a protein.

5. What are the challenges of finding proteins of unknown structure?

One of the main challenges is obtaining a sufficient amount of the protein for analysis. Other challenges include identifying the most appropriate method for determining the structure, interpreting the data accurately, and solving any technical issues that may arise during the process.

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