Magnetic torque on cell membrane by MNPs

[TESL@]

Hello,

Suppose sinosodial AC and pulsed DC magnetic fields with equal rms are applied on animal cells in the presence of magnetic nanoparticles. For the mean field strengths to be equal, the peak value of the square wave (with 50% duty cycles) must be sqrt. 2, which means that the maxiumum field strength of DC will be higher than that of AC. This will lead to a greater torque on the nanoparticles.

My question is if the nanoparticles are near or attached to cell membrane, will the elastic stress on the membrane be responsible for more nanoparticle entering cell than AC field? I can predict such mechanism but I need reliable sources. Any piece of information is appreciated,

Thank you.

edit: Question2. If you know anything about magnetic fields affecting the permeability of cell membrane, please share.

 

[Ryan_m_b]

Perhaps it's my lack of knowledge wrt electrical and magnetic engineering but I can't quite tell what you are proposing. Magnetic nanoparticles are an active area of research for drug delivery, have you looked into this at all? You can easily find a lot of literature. Here's a fairly recent review on the topic:

Magnetic nanoparticles and drug delivering, 2010
http://www.sciencedirect.com/science/article/pii/S1043661810000289

Magnetic nanoparticles (MNPs) are being of great interest due to their unique purposes. Especially in medicine, application of MNPs is much promising. MNPs have been actively investigated as the next generation of targeted drug delivery for more than thirty years. The importance of targeted drug delivery and targeted drug therapy is to transport a drug directly to the centre of the disease under various conditions and thereby treat it deliberately, with no effects on the body. Usage of MNPs depends largely on the preparation processes to select optimal conditions and election agents to modify their surface. This review summarizes the most commonly used functionalization methods of the MNPs preparation methods and their use in targeted drug delivery and targeted therapy.

 

[TESL@]

Ryan m b, I am quite into the subject but thank you anyways. I am asking for an explanation of nanoparticles inside pulsed DC penetrating the membrane more than AC fields, preferably with examples.

 

[Dale]

Why would increased max torque preferentially cause particles to enter the cell?

Cellular uptake of superparamagnetic iron oxide particles has quite a bit of literature. It seems that the predominant pathway is through endocytosis. I don't know how torque would affect endocytosis. That is a process that is more mediated by surface chemicals and labels and so forth. Here is a tutorial:

http://www.jnanobiotechnology.com/content/pdf/1477-3155-11-S1-S7.pdf

 

[LudusRex]

Hello,

Thank you for your question. The effect of magnetic fields on cell membranes and the entry of nanoparticles is an area of ongoing research and there is still much to be understood. However, there are some studies that have investigated the influence of magnetic fields on cell membrane permeability.

One study published in the Journal of Applied Physics found that exposure to a pulsed magnetic field increased the permeability of red blood cell membranes, allowing for easier entry of nanoparticles. This was attributed to the formation of transient pores in the membrane due to the mechanical stress caused by the magnetic field.

Another study published in the Journal of Biomedical Materials Research found that magnetic nanoparticles attached to cell membranes can induce changes in the membrane structure, leading to increased permeability. This was seen in both AC and DC magnetic fields.

Overall, it appears that both AC and DC magnetic fields can affect cell membrane permeability and potentially influence the entry of magnetic nanoparticles. However, the exact mechanisms and the extent of this effect are still being studied and more research is needed to fully understand this phenomenon.

I hope this information is helpful. Thank you.