- #1
Eagle9
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Citation:
So, the Ampiox suppress the synthesis of peptidoglycane that are absolutely necessary for cell walls, also it inhibits the enzyme called transpeptidase that “cross-links peptidoglycan chains to form rigid cell walls” (http://en.wikipedia.org/wiki/DD-transpeptidase ) and all these action leads to bacterial lysis. This is clear, but imagine some certain (one) bacterium that already has got both transpeptidase and peptidoglycanes in its cell wall in a necessary amount and therefore this bacterium does not need any additional transpeptidase and/or peptidoglycanes. The question: can Ampiox cause lysis of this bacterium? If transpeptidase and/or peptidoglycanes are degraded (http://en.wikipedia.org/wiki/Protein_degradation ) from time to time (because of various reasons) then they need to be synthesized and replaced by new molecules. If so, then I can understand why Ampiox causes lysis: old transpeptidase and peptidoglycanes molecules are degraded, new ones cannot be created and the bacteria die.
But if both transpeptidase and peptidoglycanes are relatively long-live then Ampiox cannot cause the lysis, at least Ampiox cannot destroy the already-existing bacteria. As for newly created bacteria (after/during Cell division) that are growing and probably need more and more transpeptidase and peptidoglycanes they (bacteria) can be subjected to Ampiox action.
So, could you please tell me how exactly Ampiox act on bacteria?
http://www.igenericdrugs.com/?s=AmpioxAmpiox is a broad-spectrum antibiotic that contains two active ingredients: Ampicillin and Oxacillin. Ampicillin and Ampiox belong to a group of preparations called penicillin antibiotics. Ampicillin and Ampiox interferes with the ability of the bacteria to form cell walls. Bacterial cell walls protect cells from entering the foreign substances inside the cells and stop the contents of cells from leaking out. Ampicillin and Ampiox work by inhibiting enzyme transpeptidase, disturbing the synthesis of peptidoglycane that is essential component in bacterial cell walls. This causes hole to appear in the bacterial cell walls resulting in lysis of the bacteria. Ampiox is effective against wide variety of Gram-positive and Gram-negative bacteria.
So, the Ampiox suppress the synthesis of peptidoglycane that are absolutely necessary for cell walls, also it inhibits the enzyme called transpeptidase that “cross-links peptidoglycan chains to form rigid cell walls” (http://en.wikipedia.org/wiki/DD-transpeptidase ) and all these action leads to bacterial lysis. This is clear, but imagine some certain (one) bacterium that already has got both transpeptidase and peptidoglycanes in its cell wall in a necessary amount and therefore this bacterium does not need any additional transpeptidase and/or peptidoglycanes. The question: can Ampiox cause lysis of this bacterium? If transpeptidase and/or peptidoglycanes are degraded (http://en.wikipedia.org/wiki/Protein_degradation ) from time to time (because of various reasons) then they need to be synthesized and replaced by new molecules. If so, then I can understand why Ampiox causes lysis: old transpeptidase and peptidoglycanes molecules are degraded, new ones cannot be created and the bacteria die.
But if both transpeptidase and peptidoglycanes are relatively long-live then Ampiox cannot cause the lysis, at least Ampiox cannot destroy the already-existing bacteria. As for newly created bacteria (after/during Cell division) that are growing and probably need more and more transpeptidase and peptidoglycanes they (bacteria) can be subjected to Ampiox action.
So, could you please tell me how exactly Ampiox act on bacteria?