Brown Norway rat genome

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In summary, an international collaboration of genome sequencing teams has successfully obtained the complete genome sequence of the brown Norway rat using a combination of whole genome shotgun and clone-by-clone approaches. This draft covers over 90% of the rat genome and has revealed that the rat is an important model organism for studying human diseases. The team's success also provides insight into how to handle upcoming primate genomes. As for the Norwegian Blue Parrot genome, there is currently no report of its sequencing.
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Brown Norway rat genome obtained from whole genome shotgun and clone-by-clone approach | By Cathy Holding

An international collaboration of genome sequencing teams previously at odds over strategy puts aside its differences this week in Nature to publish the third complete mammalian genome sequence. The Rat Genome Sequencing Project Consortium combined whole genome shotgun (WGS) methodology with a clone-by-clone approach to produce a high-quality draft covering over 90% of the brown Norway rat (Rattus norvegicus) genome.

[...]

The rodent–human genomic comparison reveals that all but a handful of human disease gene orthologs are present, underscoring the importance of the rat as a model organism of human disease, according to Christopher P. Ponting, professor of bioinformatics at the University Of Oxford and a member of the team. “I think this gives us an idea of how to handle the primate genomes that are going to come online soon, so the observations provide a foretaste of the fruits of comparing our genome—the human genome—with those of other primates,” he said.

http://www.biomedcentral.com/news/20040331/01[/URL]

http://www.nature.com/nsu/040329/040329-11.html

http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v428/n6982/full/nature02426_fs.html
 
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When will the report the Norwegian Blue Parrot genome?

(I'm terribly sorry, I just couldn't pass up the opportunity)
 
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Thank you for sharing this information about the Brown Norway rat genome. It is fascinating to see the collaboration and combination of different approaches in producing a high-quality draft of the genome. The comparison with the human genome is also intriguing, as it highlights the importance of the rat as a model organism for studying human diseases. I agree with Christopher P. Ponting's statement that this can provide valuable insights for handling future primate genomes. The availability of this genome sequence will undoubtedly lead to further advancements in understanding the genetic basis of diseases and developing treatments. Overall, this is a significant achievement in the field of genomics and has the potential to impact various areas of research.
 

1. What is the Brown Norway rat genome?

The Brown Norway rat genome is the complete set of genetic material that is found in the Brown Norway rat, also known as Rattus norvegicus. This includes all of the DNA sequences and genes that make up the genetic code of this species.

2. How was the Brown Norway rat genome sequenced?

The Brown Norway rat genome was sequenced using a combination of cutting-edge sequencing technologies, including next-generation sequencing methods. This involved breaking down the DNA into small fragments, sequencing each fragment, and then assembling the fragments back together to create the full genome sequence.

3. What information can be gained from studying the Brown Norway rat genome?

Studying the Brown Norway rat genome can provide valuable insights into the genetic basis of various traits and diseases in rats. It can also shed light on the evolutionary history of rats and their relationship to other species. Additionally, this information can be used for biomedical research, such as developing rat models for human diseases.

4. How does the Brown Norway rat genome compare to other rat genomes?

The Brown Norway rat genome is considered to be the reference genome for rats, meaning that it is the most complete and accurate representation of the rat genome. It is also highly similar to the genomes of other rat strains, with an estimated 99% similarity to the genomes of other inbred rat strains.

5. Are there any ethical concerns surrounding the study of the Brown Norway rat genome?

Like with any research involving animals, there are ethical considerations that must be taken into account when studying the Brown Norway rat genome. This includes ensuring humane treatment of the animals and obtaining proper approval from ethics committees. Additionally, measures must be taken to minimize any potential harm to the rats during the sequencing process.

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