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hivesaeed4
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I read that reduced/low penetrance occurs due to environmental and genetic factors. Could someone state such factors and if possible also provide examples.
Cheers!
Cheers!
Reduced penetrance refers to a phenomenon in genetics where individuals who carry a disease-causing gene mutation do not necessarily develop the associated disease or exhibit its symptoms.
There are several factors that can contribute to reduced penetrance, including genetic modifiers, environmental factors, and stochastic events such as random mutations or epigenetic changes.
Genetic modifiers are genes that can alter the expression of a disease-causing gene mutation. These modifiers can either increase or decrease the likelihood of developing the associated disease, thus affecting penetrance.
Yes, environmental factors such as diet, lifestyle, and exposure to toxins or pathogens can influence the expression of a disease-causing gene mutation. They can also interact with genetic modifiers to further affect penetrance.
This can be attributed to the complex interplay of genetic and environmental factors, as well as stochastic events, that can affect the expression of a disease-causing gene mutation. Additionally, the presence of genetic modifiers can also play a role in determining penetrance. Further research is needed to fully understand this phenomenon.