Anti-depressants may help grow new brain cells.

In summary, an article on MSN reports that anti-depressants have been found to help increase brain cell activity, which could potentially lead to a "smart pill." However, there are conflicting studies on the effectiveness of these medications and they can also have a range of side effects. The article also raises questions about the credibility of the study, as the pharmaceutical company that manufactures one of the drugs used in the study is a major contributor to the university where it was conducted.
  • #1
Kerrie
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http://content.health.msn.com/content/article/72/81660.htm

i found this quite interesting that anti-depressants help the activity of increasing brain cells...
 
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  • #2
Originally posted by Kerrie
http://content.health.msn.com/content/article/72/81660.htm

i found this quite interesting that anti-depressants help the activity of increasing brain cells...

Interesting! Perhaps this could lead to a smart pill.
 
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  • #3
From the MSN article ..." it takes weeks for the drugs to have an effect on depression. "

There are many studies that say just the opposite . Some conclude that these medications are effective as or are similar to placebos , such as :

http://journals.apa.org/prevention/volume1/pre0010002a.html

http://www.journals.apa.org/prevention/volume5/pre0050023a.html

http://journals.apa.org/prevention/volume5/pre0050025c.html

Whom to believe ?

" Antidepressant drugs help people with depression and anxiety "

Many of the SSRI's have "anxiety" listed as a "frequent adverse effect " . Also listed as "frequently" occurring for some SSRI's are " psychosis and mania "

Checking Yale's website this report is almost three years old .

http://www.yale.edu/opa/newsr/00-12-15-01.all.html

Why the sudden repeat by major media ? According to the Yale news release , the drugs used were " ...amonoamineoxidase inhibitor (tranlcypromine), a serotonin-selective reuptake inhibitor (fluoxetine), and a norepinephrine-selective reuptake inhibitor (reboxetine). "

Eli Lilly and Co. ( manufacturer of Prozac ) has the side effects listed for Fluoxetine :

Frequent - Prozac (Fluoxetine) Side Effects :

Allergic or Toxic:
Rash, Pruritus (skin inflammation).

Neurological:
Headache, Tremor, Dizziness, Asthenia.

Behavioral:
Insomnia, Anxiety, Nervousness, Agitation, Abnormal dreams, Drowsiness and fatigue.

Autonomic:
Excessive sweating

Gastrointestinal:
Nausea, Disturbances of appetite, Diarrhea.

Respiratory:
Bronchitis, Rhinitis (inflammation of the nasal mucous membranes), Yawning.

Endocrine:
Weight loss.

Musculoskeletal:
Muscle pain, Back pain, Joint pain.

Urogenital:
Painful menstruation, Sexual dysfunction, Urinary tract infection, Frequent micturition.

Miscellaneous:
Chills

Infrequent - Prozac (Fluoxetine) Side Effects:

Allergic or Toxic: Chills and fever, Urticaria, Maculopapular rash.
Neurological: Abnormal gait, Ataxia, Akathisia, Buccoglossal syndrome, Hyperkinesia, Hypertonia, incoordination, Neck rigity, extrapyramidal syndrome, Convulsions, Photophobia, Myoclonus, Vertigo, Migraine, Tinnitus, Hypesthesia, Neuralgia, Neuropathy, Acute brain syndrome.
Behavioral: Confusion, Delusions, Hallucinations, manic reaction, Paranoid reaction, Psychosis, Depersonalization, Apathy, Emotional Lability, Euphoria, Hostility, Amnesia, Increased libido.
Autonomic: Dry mouth, Constipation, Urinary retention, Vision disturbance, Diplopia, Mydriasis, Hot flushes.
Cardiovascular: Chest pain, Hypertension, Syncope, Hypotension, Angina pectoris, Arrhythmia, Tachycardia. Gastrointestinal: Vomiting, Stomatitis, Dysphagia, Eructation, Esophagitis, Gastritis, Gingivitis, Glossitis, Melena, Thirst, Abnormal liver function test.
Respiratory: Asthma, Dyspnea, Hyperventilation, Pneumonia, Hiccups, Epistaxis.
Endocrine: Generalized edema, Peripheral edema, Face edema, Tongue edema, Hypoglycemia, Hyperprolactinemia, Weight gain. Hematoligic: Anemia, Lymphadenopathy, Hemorrhage. Dermatologic: Acne, Alopecia, Dry skin, Herpes simplex,
Musculoskeletal: Arthritis, Bone pain, Bursitis, Tenosynovitis, Twitching.
Urogenital: Abnormal ejactulation, Impotance, Menopause, Amenorrhea, Menorrhagia, Ovarian disorder, Vaginitis, Leukorrhea, Fibrocystic breast, Breast pain, Cystitus, Dysuria, Urinary urgency, Urinary incontinence.
Miscellaneous: Amblyopia, Conjunctivitis, Cyst, Ear pain, Eye pain, Jaw pain, Neck pain, Pelvic pain, Hangover effect and Malaise.

Rare - Prozac (Fluoxetine) Side Effects

Allergic or Toxic: Allergic reaction, Erythema multiforme, Vesiculobullous, Rash, Serum sickness, Contact dermatitis, Erthema nodosum, Purpuric rash, Leukocytoclastic vasculitis, Leukopenia, Thrombocythemia, Arthralgia, Angioedema, Bronchospasm, Lung fibrosis, Allergic alveolitis, Larynx edema and Respiratory distress.
Neurological: Dysarthria, Dystonia, torticollis, Decreased reflexes, Nystagmus, Paralysis, Paresthesia, Carpal tunnel syndrome, Stupor, Coma, Abnormal EEG, Chronic brain syndrome, Dyskinesia and movement disorders (including worsening of preexisting conditions or appearance in patients with risk factors {e.g., Parkinson's disease, treatment with neuroleptics or other drugs known to be associated with movement disorders})
Behavioral: Antisocial reaction, Hysteria, Suicidal ideation and violent behaviors. Cardiovascular: Bradycardia, Ventricular arrhythmia, First degree A V block, Bundle branch block, Myocardial infarct, Cerebral ischemia, Cerebral vascular accident, Thrombophlebitis.
Gastrointestinal: Bloody diarrhea, Hematemesis, Gastrointestinal hemorrhage, Duodenal ulcer, Stomach ulcer, Mouth ulceration, Hyperchlorhydria, Colitis, Enteritis, Cholecystitis, Hepatitis, Hepatomegaly, Liver tenderness, Jaundice, Increased salivation, Salivary gland enlargement, Tongue discoloration, Fecal incontinence, Pancreatitis. Respiratory: Apnea, Lung edmea Hypoxia, Pleural effusion, Hemoptysis.
Endocrine: Dehydration, Gout, Goitre, Hyperthyrodism, Hypercholesteremia, Hyperglycemia, Hypothyroidism, Weight gain.
Hematologic: Bleeding time increased, Leukocytosis, Lymphocytosis, Thrombocytopenia, Thrombocytopenic purpura, Thrombocythemia, Retinal hemorrhage, Petechia, Purpura, Sedimentation rate increased, Aplastic anemia, Pancytopenia, Immune-related hemolytic anemia.
Dermatologic: Eczema, Psoriasis, Seborrhea, Skin hypertrophy, Skin discoloration, Herpes zoster, Fungal dermatitis, Hirsutism, Ecchymoses. Musculoskeletal: Bone necrosis, Osteoporosis, Pathological fracture, Chrondrodystrophy, Myositis, Rheumatoid arthritis, Muscle hemorrhage.
Urogenital: Breast enlargement, Galactorrhea, Abortion, Dyspareunia, Uterine spasm, Vaginal hemorrhage, Metrorrhagia, Hematuria, Albuminuria, Polyuria, Pyuria, Epididymitis, Orchitis, Pyelonephritis, Salpingitis, Urethritis, Kidney calculus, Urethral pain, Urolithiasis. Miscellaneous: Abdomen enlarged, Blepharitis, Cataract, Corneal lesion, Glaucoma, Iritis, Ptosis, Strabismus, Deafness, Taste loss, moniliasis, Hydrocephalus, LE syndrome.

---------------------------------

Note : Eli Lilly is a major contributor to Yale !
 
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  • #4
Yes, I read that article a while back and thought it was interesting.

Interesting! Perhaps this could lead to a smart pill.

That would be great (because I would buy the entire stock of it) but that goes into that question on whether "smartness" is biological or environmental.
 

1. How do anti-depressants help grow new brain cells?

Anti-depressants work by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine. These neurotransmitters play a role in regulating mood and emotions. By increasing their levels, anti-depressants can promote the growth and survival of new brain cells.

2. Is there evidence to support the claim that anti-depressants can help grow new brain cells?

Yes, there have been several studies that have shown an increase in neurogenesis (the formation of new brain cells) in individuals taking anti-depressants. However, more research is needed to fully understand the mechanisms behind this process.

3. Can anti-depressants reverse the damage caused by depression on the brain?

While anti-depressants can promote the growth of new brain cells, they cannot reverse any damage that may have already been caused by depression. However, by treating depression and promoting neurogenesis, anti-depressants may help improve brain function and overall well-being.

4. Are all anti-depressants equally effective in promoting neurogenesis?

No, different types of anti-depressants may have varying effects on neurogenesis. For example, selective serotonin reuptake inhibitors (SSRIs) have been shown to promote neurogenesis, while other types of anti-depressants may not have the same effect. Additionally, the effectiveness of anti-depressants in promoting neurogenesis may vary from person to person.

5. Can anti-depressants alone promote the growth of new brain cells?

No, anti-depressants should not be viewed as a standalone treatment for promoting neurogenesis. Other factors, such as lifestyle habits (exercise, diet, etc.) and therapy, also play a role in promoting brain health and neurogenesis. Anti-depressants should be used in conjunction with other treatments for optimal results.

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