Ribose and Deoxyribose - Most Common Form?

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In summary, the most common form of deoxyribose is Ribose and 2-deoxyribose, and it is not common to find 3 or 4 deoxyribose. The enzyme ribonucleotide reductace, which is responsible for the reduction reaction of ribonucleotides, consists of two domains and utilizes a free radical process. The double bond to oxygen is important for energetics, but the enzyme's binding and shape are crucial for regiochemistry.
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ssb
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Here is a drawing of Ribose and 2-deoxyribose.
My question is this the most common form of deoxyribose? Is it common to find 3 or 4 deoxyrybose?

My guess is that this is the most common because of stabilization from the double bond on the oxygen... but just want to double check. Thanks!

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The enzyme ribonucleotide reductace is responsible for the reduction reaction for the ribonucleotides. It consists of two domains (subunits). The reduction is a free radical process. One of the domains generates the free radical and the other binds to the ribose sugar and accepts the free radical. The free radical (a sulfhydryl group) abstracts a hydrogen from the C-3' of the ribose and promotes the release of the hydroxyl on the C-2' of the ribose. The C-2' position accepts a hydride from the enzyme and pushes the radical back to the C-3' position which is reprotonated by the same sulfhydryl that produced the radical in the first step.

The double bond to oxygen is important to the energetics but the enzyme binding/shape is important to the regiochemistry.
 
  • #3
chemisttree said:
The enzyme ribonucleotide reductace is responsible for the reduction reaction for the ribonucleotides. It consists of two domains (subunits). The reduction is a free radical process. One of the domains generates the free radical and the other binds to the ribose sugar and accepts the free radical. The free radical (a sulfhydryl group) abstracts a hydrogen from the C-3' of the ribose and promotes the release of the hydroxyl on the C-2' of the ribose. The C-2' position accepts a hydride from the enzyme and pushes the radical back to the C-3' position which is reprotonated by the same sulfhydryl that produced the radical in the first step.

The double bond to oxygen is important to the energetics but the enzyme binding/shape is important to the regiochemistry.

Thanks! outstanding
 

Related to Ribose and Deoxyribose - Most Common Form?

1. What is the difference between ribose and deoxyribose?

Ribose and deoxyribose are both simple sugars, or monosaccharides, that are important components of nucleic acids. The main difference between them is that ribose has one more oxygen atom than deoxyribose, hence the prefix "deoxy" which means "lacking oxygen". This difference in structure also affects their roles in the body.

2. What is the most common form of ribose and deoxyribose?

The most common form of ribose and deoxyribose is the pentose form, meaning that they have 5 carbon atoms. This is the form that is found in nucleic acids such as DNA and RNA.

3. How are ribose and deoxyribose used in the body?

Ribose is an important component of ATP (adenosine triphosphate), which is the main source of energy for cellular processes. It is also a building block for RNA, which plays a role in protein synthesis. Deoxyribose, on the other hand, is a key component of DNA, the genetic material of all living organisms.

4. Can ribose and deoxyribose be found in foods?

Ribose and deoxyribose are rarely found in foods as they are typically broken down during digestion. However, they can be found in foods high in nucleic acids, such as organ meats, fish, and legumes. Additionally, ribose can be found in some sports drinks and supplements, as it is believed to aid in muscle recovery.

5. What happens to ribose and deoxyribose when they are exposed to heat or other environmental factors?

Ribose and deoxyribose are relatively stable molecules and do not undergo significant changes when exposed to heat or other environmental factors. However, they can be degraded by enzymes in the body, which is why DNA and RNA are constantly being synthesized and broken down.

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