Memory B and T Cells: How Many and How Long?

[biophysics]

I've learned about memory B and T cells. I'm wondering how many of each a person has for a specific antigen? How long do they live?

 

[Monique]

I don't know the exact numbers, but when you look at tetanus vaccinations you need to get a booster after 10 years. So they can live up to ten years.

Here a study who looked at it in detail: http://www.jimmunol.org/cgi/content/full/171/10/4969#F1

In this study, we demonstrate that smallpox vaccine-specific memory B cells last for >50 years in immunized individuals. Virus-specific memory B cells initially declined postimmunization, but then reached a plateau 10-fold lower than peak and were stably maintained for >50 years after vaccination at a frequency of 0.1% of total circulating IgG+ B cells. These persisting memory B cells were functional and able to mount a robust anamnestic Ab response upon revaccination.

 

[oswaler]

I can provide some information on memory B and T cells. The number of memory B and T cells that a person has for a specific antigen can vary depending on the individual's immune system and exposure to that particular antigen. However, it is estimated that the average person has around 10^11 (100 billion) memory B cells and 10^10 (10 billion) memory T cells in their body.

In terms of longevity, memory B and T cells can live for many years, even decades. Studies have shown that memory B cells can persist for up to 60-70 years, while memory T cells can have a lifespan of 8-15 years. However, their lifespan can also be influenced by factors such as age and overall health.

It is important to note that the number and lifespan of memory B and T cells can also be affected by various diseases and medical treatments. For example, certain diseases like HIV can deplete memory T cells, while chemotherapy can affect the production of memory B cells.

In conclusion, the number and lifespan of memory B and T cells can vary from person to person and can also be influenced by various factors. It is a complex and dynamic system that plays a crucial role in our immune response to specific antigens. Further research is needed to fully understand the intricacies of memory B and T cells and their role in the immune system.