Does testosterone increase cortisol's effects on the brain?

In summary: It is an adrenal steroid that is converted to testosterone in the body. DHEA is known to have anti-cortisol effects, which means it blocks the effects of cortisol. This can lead to a rise in cortisol levels, as the body tries to compensate for the resistance to cortisol. This overall has a pro-anabolic effect, as it blocks the catabolic effects of cortisol.However, the question is whether this resistance to cortisol also applies to the brain, or if the brain still experiences the usual effects of elevated cortisol. This is not a normal condition, but rather a directional sensitivity to cortisol. More context is needed to fully understand the effects of DHEA-induced cortisol resistance on the brain.
  • #1
treehouse
105
0
I read in Dr. Ivy's book* that testosterone blocks the effects of cortisol and causes cortisol levels to rise in response to this cortisol resistance but has a net pro-anabolic effect (I guess in part because it blocks cortisol's catabolic effects and the body will not totally normalize the effects of cortisol on the body in response to testosterone-induced cortisol resistance). What I'm wondering is, "Does testosterone make the brain resistant as well, or does it suffer all the usual effects of elevated cortisol?"

Note that such 'cortisol resistance' is not equivalent to the medical diagnosis; in this context, it refers only to a directional sensitivity to cortisol.

*http://medicalxpress.com/news/2011-06-chocolate-athletes-leg-up.html
 
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  • #2
You're going to need to explain a lot more context here. The link you provided wasn't to a book, or anything about steroids. It was a news report about a study on milk vs. energy drinks following exercise. Looking at that author's publication history in PubMed, that seems to be the extent of his expertise, quite a lot of studies focusing on proteins vs. carbohydrates on different parameters of muscle function, development and injury under various exercise conditions. I see nothing that has anything to do with any role of steroids in his publications.

So, what conditions is he saying have to do with this testosterone-induced cortisol resistance? That's not a "normal" condition, so what are the experimental conditions cited? (Does he provide a reference in his book?) Without knowing more, I can't even begin to answer your question about whether this is a global effect, an effect at the hypothalamic level, pituitary level, or adrenal level.
 
  • #3
It is not testosterone per ce, but 5-Dehydroepiandrosteron (DHEA).
 

Related to Does testosterone increase cortisol's effects on the brain?

1. What is the relationship between testosterone and cortisol in the brain?

The relationship between testosterone and cortisol in the brain is complex and not fully understood. Testosterone is a male sex hormone that has been linked to aggression, mood, and cognitive function. Cortisol is a stress hormone that helps regulate the body's response to stress. While some studies suggest that testosterone may increase the effects of cortisol on the brain, more research is needed to fully understand this relationship.

2. Does testosterone always increase cortisol's effects on the brain?

No, testosterone does not always increase cortisol's effects on the brain. Studies have shown that the relationship between these two hormones can vary based on individual differences and the context of the situation. Additionally, the timing and amount of testosterone and cortisol released can also impact their effects on the brain.

3. Can high levels of testosterone lead to increased cortisol levels in the brain?

While there is some evidence that high levels of testosterone may be associated with increased cortisol levels in the brain, the exact mechanisms are not fully understood. Some research suggests that chronic stress and high levels of cortisol may actually decrease testosterone levels in the body. More studies are needed to fully understand the possible links between these hormones.

4. Are there any potential negative effects of testosterone and cortisol on the brain?

Both testosterone and cortisol play important roles in the body, but high levels of either hormone can have negative effects on the brain. For example, chronic stress and high levels of cortisol have been linked to memory and cognitive impairments, while high levels of testosterone have been associated with increased risk-taking behavior and aggression. It's important to maintain a balance of these hormones for optimal brain function.

5. Can testosterone and cortisol levels be controlled to optimize brain function?

While hormone levels are influenced by a variety of factors and cannot be fully controlled, there are steps that can be taken to optimize brain function. Engaging in regular physical exercise, managing stress through relaxation techniques or therapy, and maintaining a healthy diet have all been shown to positively impact hormone levels in the body. It's important to consult with a healthcare professional for personalized recommendations on managing hormone levels for optimal brain function.

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