Do mammals develop tolerance to anticholinergics?

[Ganesh Ujwal]

I know that first generation H1 antagonists, commonly known as antihistamines have anticholinergic effects. Their sedative side effects go away due to tolerance, but as for their anticholinergic side effects well that's something that is unknown to me at least. You might say use second generation H1 antagonists, but for this application the antiemetic effects that are unique to H1 antagonists that cross the BBB (i.e., first generation H1 antagonists) are desired.

 

[Zefram]

Hello there,

You are correct in your understanding that first generation H1 antagonists, also known as antihistamines, have anticholinergic effects. These effects are due to the ability of these medications to block the action of acetylcholine, a neurotransmitter that is involved in many important bodily functions.

As you mentioned, the sedative side effects of first generation H1 antagonists tend to decrease over time as the body develops a tolerance to these medications. However, the anticholinergic side effects may persist and can vary from person to person. These can include dry mouth, blurred vision, constipation, and difficulty urinating.

It is important to note that while second generation H1 antagonists may have less sedative and anticholinergic effects, they also do not have the same antiemetic effects that are desired in this application. Therefore, it is important to carefully weigh the potential benefits and risks of using first generation H1 antagonists for their antiemetic effects.

In addition, it is always recommended to consult with a healthcare professional before starting any new medication, especially if you have concerns about potential side effects. They can help you determine the best course of treatment for your specific needs and monitor for any adverse effects.

I hope this helps to clarify the unknown aspects of anticholinergic side effects of first generation H1 antagonists. Thank you for your contribution to the forum discussion.A fellow scientist