Combinatorial chem - Stills binary code tag system

In summary, the binary code tag system uses aryl halides attached to the linker to represent different building blocks in a synthesis process, allowing for efficient encoding and tracking of compounds in a library.
  • #1
mycotheology
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In my med chem book:
http://books.google.ie/books?id=Qe9...ge&q=chemistry binary code tag system&f=false
they talk about a method of tagging in which you attach aryl halides to the linker then use gas chromatography to get a "bar code" which tells you what building blocks were used to synthesize each compound. I don't get it at all. Are these aryl halides attached to the link in a sequence or is it just a single aryl halide attached to a linker at a time? How can these aryl halides tell you what building block was used at what stage? For example, in table 5.3 they show you an example of an encoding system and they say T1 for glycine, T2 for alanine and T1 + T2 for serine. How would they attach T1 and T2 to the same resin bead? Does this method only work for tiny libraries? For example how would you apply this method to library of tripeptides made up of 20 different amino acids? You would need loads of different aryl halides.
 
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  • #2
The binary code tag system works by attaching aryl halides to the linker at each stage of the synthesis. Each aryl halide is given a different code, and the codes are used to represent different building blocks. For example, if T1 represents glycine, T2 represents alanine, and T3 represents serine, then attaching T1, T2 and T3 to the linker in sequence would represent the synthesis of serine from glycine and alanine. This method can be used for larger libraries as well, though it may require more aryl halides. For example, if you were making a library of tripeptides with 20 different amino acids, you would need to use at least 20 different aryl halides, one for each amino acid. You could also use fewer aryl halides if you had a set of codes that represented combinations of amino acids.
 

Related to Combinatorial chem - Stills binary code tag system

1. What is combinatorial chemistry?

Combinatorial chemistry is a technique used in drug discovery and materials science that involves creating large numbers of molecules or materials by systematically combining different building blocks or components.

2. What is the Stills binary code tag system?

The Stills binary code tag system is a method for encoding and decoding molecules or building blocks in combinatorial chemistry. It involves using binary tags to represent each building block, allowing for efficient and accurate tracking and identification of individual components in a large library of molecules.

3. How does the Stills binary code tag system work?

The Stills binary code tag system works by assigning a unique binary code to each building block or molecule in a combinatorial library. The code is based on a series of binary digits (0s and 1s) that correspond to specific chemical functional groups or building block characteristics. By combining different tags, a large number of unique codes can be generated, allowing for the creation of a diverse library of molecules.

4. What are the benefits of using the Stills binary code tag system?

The Stills binary code tag system offers several benefits for combinatorial chemistry. It allows for efficient and accurate tracking of building blocks, making it easier to identify and isolate desired molecules. It also enables the creation of large and diverse libraries of molecules, increasing the chances of finding potential drug leads or novel materials. Additionally, the use of binary codes reduces the time and cost associated with traditional methods of molecular identification.

5. Are there any limitations to the Stills binary code tag system?

While the Stills binary code tag system offers many advantages, it also has some limitations. It requires specialized equipment and software for encoding and decoding molecules, which may not be readily available in all laboratories. Additionally, the system is limited to representing a finite number of building blocks, so it may not be suitable for libraries containing a large number of unique molecules.

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