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With this year's Nobel prize for physiology going to autophagy related research, the interest in autophagy and its roles in health and disease is rekindled.
Autophagy is an important cellular process which clears the cell debris and promotes health. So the autophagy process should never be interfered with for good health.
It is surmised that Type-2 diabetes is a condition where autophagy is an on-going process or interrupted process. If the process of autophagy of pancreatic beta/alpha cells is completed on its own, the disease would resolve on its own.
It is well known that Glucagon is a major inducer of autophagy in liver. Glucagon promotes glycolysis, causing an increase in blood plasma glucose. It suppresses insulin. Exactly the same conditions we experience in Type-2 diabetes.
Then the raised glucose/glucagon levels and suppressed insulin levels are quite normal and expected. If so, why should we see diabetes as an abnormal condition? Once the autophagy mechanism which is currently active and when the removal of cell debris work is over, things should fall into their place.
My question is why don't we consider Type-2 Diabetes as a transient condition and glucose would come down to normal levels once the autophagy mechanism has finished its job. Should we 'treat' diabetes at all?
Autophagy is an important cellular process which clears the cell debris and promotes health. So the autophagy process should never be interfered with for good health.
It is surmised that Type-2 diabetes is a condition where autophagy is an on-going process or interrupted process. If the process of autophagy of pancreatic beta/alpha cells is completed on its own, the disease would resolve on its own.
It is well known that Glucagon is a major inducer of autophagy in liver. Glucagon promotes glycolysis, causing an increase in blood plasma glucose. It suppresses insulin. Exactly the same conditions we experience in Type-2 diabetes.
Then the raised glucose/glucagon levels and suppressed insulin levels are quite normal and expected. If so, why should we see diabetes as an abnormal condition? Once the autophagy mechanism which is currently active and when the removal of cell debris work is over, things should fall into their place.
My question is why don't we consider Type-2 Diabetes as a transient condition and glucose would come down to normal levels once the autophagy mechanism has finished its job. Should we 'treat' diabetes at all?