I guess there would be a constant battle between Anonymous and the space commies. The hackers would have to figure out how to hack their implants so they cannot be tracked.
Or an invasion of a messy and annoying parasite like the flood.
I am going to write a scifi comic and it has technology that we would see in the 22nd century. People have become spacefaring and they have built colonies on the moon and mars. Nanotechnology, robots and AI such as Cortana are commonplace. Extinct species can be cloned along with a lot of other...