Recognize this irreversible equation for kinetic modeling?

[Dopplerganger]

Hi all,
I'm trying to come up with velocity equations for a multi-enzymatic system and came across this velocity equation. Does anyone recognize this equation?

There was no citation or derivation and the variables were not explained. This is my guess:

• P, Q, A, B are concentrations of some sort
• Keq is the equilibrium constant
• Ka, Kb, Kp, Kq are the Michaelis constants

I also find it odd that I found this under the "2 substrates" section, because it seems like there are 4 substrates here. If anyone has anything to contribute regarding this equation, I'd be very thankful!

 

[Achy47]

Hello,

I am a scientist with experience in enzymology and I may be able to help with your question. The velocity equation you have mentioned appears to be a general equation for a multi-enzymatic system, and is commonly used in biochemical kinetics. However, without more information about the specific system and variables involved, it is difficult to provide a definitive answer.

Based on the variables you have mentioned, it seems like this equation may be describing a reaction involving two substrates (P and Q) and two enzymes (A and B). The equilibrium constant (Keq) would represent the ratio of products to substrates at equilibrium, while the Michaelis constants (Ka, Kb, Kp, and Kq) would indicate the substrate concentrations at which the enzymes are half-saturated.

It is possible that this equation was derived from a specific experimental system or model, so it would be helpful to know where you found it. Additionally, it may be useful to provide more context and information about the system you are studying, such as the type of reaction or the specific enzymes and substrates involved. This would allow for a more accurate interpretation of the equation and its potential applications.

I hope this helps, and I would be happy to discuss this further if you have any additional information or questions. Best of luck with your research!