Exploring the Effects of Sirtuin Activators on Human Longevity

[SpitfireAce]

Sirtuins are enzymes which repair telemeres that deteriorate to cause aging. They are normally released in response to stress such as calorie restriction or low insulin levels, but sir2 can be stimulated by certain chemicals. Why is it unfeasible to take molecules like resveratrol (found in red wine) daily in high concentration in order to release these enzymes and effectively live 40% longer with a lower risk of cancer and heart disease? Are there genuine concerns or is the FDA just ethically hesitant to approve such drugs?

 

[Ygggdrasil]

There is a lot of controversy over the roles of sirtuins and resveratrol in aging. See for example:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101544/https://www.the-scientist.com/news-opinion/anti-aging-pathway-questioned-41912https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319551/https://www.health.harvard.edu/blog/diet-rich-resveratrol-offers-health-boost-201405157153