Distinguishing Left & Right-Handed DNA: A, B, & Z Types

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In summary, the best way to determine if a DNA strand is left or right handed is to look at the direction of the backbone as it passes along the front of the molecule. If it is going up and to the right, it is right-handed, and if it is going up and to the left, it is left-handed. This technique can help in distinguishing between A, B, and Z DNA types, as well as identifying any changes in the spacing of base pairs before a twist.
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zmike
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Hi

How do I tell whether the DNA strand is left or right handed? (for some reason I keep getting right handed for all 3 types of DNA even though this shouldn't be right?)

and is there any difference between A,b,z DNA BEYond that there is a change in the spacing of bp before a twist?

thanks
 
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  • #2
Hello!
The best way, I feel, is to look at the backbone (of sugar and phosphate) as it passes along the front of the molecule: if it is going up and to the right, it's right-handed; and if it is going up and to the left, it's left-handed.
 

Related to Distinguishing Left & Right-Handed DNA: A, B, & Z Types

1. What is the difference between left-handed and right-handed DNA?

The difference between left-handed and right-handed DNA is the direction in which the double helix structure twists. In right-handed DNA, the helix twists in a clockwise direction, while in left-handed DNA, the helix twists in a counterclockwise direction.

2. What are the different types of DNA structures?

There are three main types of DNA structures - A, B, and Z. A-DNA is a right-handed helix with a more compact shape, B-DNA is the most common form and is also right-handed, and Z-DNA is a left-handed helix with a zigzag shape.

3. How is the handedness of DNA determined?

The handedness of DNA is determined by the position of the deoxyribose sugar molecules in the helix. If the sugar molecules are on the right side of the helix, it is considered a right-handed DNA, and if they are on the left side, it is considered a left-handed DNA.

4. Can left-handed DNA be found in humans?

While left-handed DNA exists in nature, it is very rare and is not found in humans. The majority of DNA in humans is right-handed B-DNA, with small amounts of A-DNA in certain regions.

5. What is the significance of distinguishing left and right-handed DNA?

Distinguishing left and right-handed DNA is important for understanding the structure and function of DNA in different organisms. It also has implications in fields such as medicine and biotechnology, as the handedness of DNA can affect how it interacts with other molecules and enzymes.

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